Season the roast all over with salt and pepper. Sprinkle on the smoked paprika and garlic powder.
Heat a large dutch oven over medium-high heat with a drizzle of avocado oil. Sear the beef on every side until golden brown and crisp. Transfer the roast to a slow cooker. Pour in the pumpkin beer.
Cook on low for 8 to 12 hours, until the beef is easily shredded.
Make the horseradish sauce - whisk everything together until combined. This is great if you let it sit in the fridge for a day or so. It gets even better! So it’s perfect to make ahead of time.
When it comes time to serve the beef, I like to shred it and turn the crockpot on high. Leave the lid off and let the beef soak up some of the juices for a bit, stirring every 5 to 10 minutes.
To serve, pile high on a bun with sharp cheddar and horseradish sauce! You can also serve it over mashed potatoes, in wraps, with grains, etc.