Preheat the oven to 425 degrees F. Line a baking sheet with parchment paper.
In a large bowl, whisk together the flour, sugar, pie spice, baking powder, salt, and baking soda.
In a smaller bowl, whisk together the pumpkin, egg, cream, milk and vanilla extract.
Add the small cold butter pieces to the bowl of dry ingredients. Use a fork, pastry cutter or your fingers to cut in the butter until it forms coarse crumbs. You want the butter in small pieces and evenly distributed through the flour.
Add the wet ingredients. Mix just until a dough forms, bringing it together with your hands. Turn onto a lightly floured surface and knead gently once or twice.
Divide the dough in half and pat each into a 6-inch round circle. Brush each scone with melted butter. Cut each round into 4 or 6 slices.
Bake the scones for 12 to 14 minutes, until the tops are slightly golden. Let them cool for a few minutes, then drizzle with the glaze and top with the coarse sugar. Let the glaze set for 10 minutes, then serve!